Research Paper Volume 13, Issue 5 pp 7096—7119
Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages
Figure 8. Berberine deacetylates TFEB by activating SIRT1. (A) The mRNA level of SIRT1 following siRNA treatment. Data was analyzed by one-way ANOVA with Tukey HSD post-hoc test (vs. Control group). (B) Acetylation levels in primary peritoneal macrophages after different treatments. Data was analyzed by one-way ANOVA with Tukey HSD post-hoc test (vs. Control group). (C) Acetylation level of TFEB in the nucleus of primary peritoneal macrophages after different treatments. All values are expressed as mean ± SD (error bars) of three independent experiments. n = 3; *p < 0.05, **p < 0.01 versus control.