Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke

Zhongfei Zhang; Xiaoxiong Zou; Run Zhang; Yu Xie; Zhiming Feng; Feng Li; Jianbang Han; Haitao Sun; Qian Ouyang; Shiting Hua; Bingke Lv; Tian Hua; Zhizheng Liu; Yingqian Cai; Yuxi Zou; Yanping Tang; Xiaodan Jiang

doi:doi:10.18632/aging.202466

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Research Paper Volume 13, Issue 2 pp 3060—3079

Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke

Figure 7. A potential mechanism contributing to the hUMSC-Exos-induced decrease in microglia-mediated neuroinflammation after ischemic stroke. After injection of hUMSC-Exos into the tail vein of the murine ischemic stroke model, they traversed the blood-brain barrier and were internalized by microglia at the site of cerebral injury. Exosomal miR-146a-5p may decrease microglia-mediated neuroinflammation by suppressing the IRAK1/TRAF6 signaling pathway.