Toxic effect of titanium dioxide nanoparticles on corneas <i>in vitro</i> and <i>in vivo</i>

Junxing Yang; Jianliang Liu; Ping Wang; Juanjuan Sun; Xiaohui Lv; Yumei Diao

doi:doi:10.18632/aging.202412

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Research Paper Volume 13, Issue 4 pp 5020—5033

Toxic effect of titanium dioxide nanoparticles on corneas in vitro and in vivo

Figure 6. TiO₂ NPs damaged corneas in vivo. (A) Images of eyeballs after indicated treatment in vivo, bar = 0.1 cm. (B) Histological observation of corneas with HE staining after TiO₂ NPs treatment, bar = 20 μm. (C) Detection of apoptotic cells in cornea of TiO₂ NPs-treated mice with TUNEL staining, bar = 20 μm. Measurement of MDA content (D), SOD activity (E) and GSH-Px activity (F) in vivo. *P<0.05, ***P<0.001.