Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI

Sergio Casta&#xF1;eda-Zegarra; Qindong Zhang; Amin Alirezaylavasani; Marion Fernandez-Berrocal; Rouan Yao; Valentyn Oksenych

doi:doi:10.18632/aging.202346

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Research Paper Volume 12, Issue 23 pp 23578—23597

Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI

Figure 4. Genetic interaction between Mri and Dna-pkcs in vivo. (A) No live-born Mri^-/-Dna-pkcs^-/- mice were detected. (B, C) Mri^-/-Dna-pkcs^-/- embryos were detected at day E14.5. (D) Body weight in milligrams (mg) from two E14.5 Mri^-/-Dna-pkcs^-/- and Mri^-/-Dna-pkcs^+/- embryos from the same litter. The mendelian ratio 1:2:1 in embryos was verified by the Chi-Square test (χ²). The χ² was 1.8 and its corresponding probability was between 25 and 50%. *Expected distribution assuming lethality.