Figure 7. Correlation between Z scores of neuropsychological tests and relative abundances of major gut bacterial genus (>1% of total OTU) of three timepoints of MAP groups. In the heatmap, Spearman correlation coefficient rho (r) are presented in red (positive correlation), white (no correlation) and green (negative correlation). The significant different correlations are presented as **** p < 0.0001, *** p ≥ 0.0001 - < 0.001, ** p ≥ 0.001 - < 0.01, * p ≥ 0.01- < 0.05. The p values were corrected by false discovery rate using the Benjamini and Hochberg method and q values were represented as # q ≥ 0.01- < 0.05. OTU= Operational taxonomical unit, MAP= Mindful awareness program, UG= Unknown genus, UF= Unknown family. MAP (both correlation parameters); n= 53 (Timepoint 1; n= 28, Timepoint 2; n= 21, Timepoint 3; n= 14).