Research Paper Volume 12, Issue 24 pp 25981—25999

Figure 2. PFN2 overexpression promotes the proliferation, migration, and invasion of SCLC cells. PFN2 expression is significantly increased in H446 cells with PFN2 overexpression (P=0.02) (A). PFN2 overexpression shows significantly improved proliferation (P=0.6133, 0.1860, 0.0956, and 0.0278 at 6 h, 12 h, 18 h, and 24 h, respectively) (B), migration (P=0.0001) (C), and invasion (P=0.018) (D) of H446 cells. PFN2 expression is significantly decreased in H446 cells with PFN2 knockdown (P=0.03) (E). PFN2 knockdown shows markedly inhibited proliferation (P=0.3740, 0.7718, 0.0114, and 0.0027 at 6 h, 12 h, 18 h, and 24 h, respectively) (F), migration (P=0.002) (G), and invasion (P=0.0301) (H) of H446 cells (n=3). Overexpression control (OC), knockdown control (KC), and wild type (WT) of H446 cells show similar proliferation (P=0.1208, 0.2105, 0.7942, and 0.03275 at 6 h, 12 h, 18 h, and 24 h respectively) (I), migration (P=0.2721) (J), and invasion (P=0.3603) (K).