Figure 1 — Proposing a minimal set of metrics and methods to predict probabilities of amyloidosis disease and onset age in individuals

Theory Article|Volume 12, Issue 22|pp. 22356–22369

Proposing a minimal set of metrics and methods to predict probabilities of amyloidosis disease and onset age in individuals

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Figure 1.Minimal kinetic mechanism for TTR homeostasis. TTR unfolded* is a transient intermediate that may not accumulate to a measurable degree. It is assumed that degradation of fibrils and aggregate is negligible compared to degradation of monomer (k_Deg2<<Deg1).