LncRNA PVT1 accelerates malignant phenotypes of bladder cancer cells by modulating miR-194-5p/BCLAF1 axis as a ceRNA

Mingwei Chen; Rongyuan Zhang; Le Lu; Jian Du; Chunyang Chen; Keke Ding; Xuedong Wei; Guangbo Zhang; Yuhua Huang; Jianquan Hou

doi:doi:10.18632/aging.202203

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Research Paper Volume 12, Issue 21 pp 22291—22312

LncRNA PVT1 accelerates malignant phenotypes of bladder cancer cells by modulating miR-194-5p/BCLAF1 axis as a ceRNA

Figure 7. PVT1 positively regulates BCLAF1 expression via sponging miR-194-5p. Knockdown BCLAF1 significantly reversed cell proliferation promotion induced by Overexpression PVT1(EdU, A, B, CCK8, C, D). Knockdown BCLAF1 significantly reversed cell migration promotion induced by overexpression PVT1(E, F). Knockdown BCLAF1 significantly reversed cell apoptosis inhibition induced by overexpression PVT1 (G, H). (*P < 0.05, **P < 0.01).