Research Paper Volume 13, Issue 1 pp 877—893
Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGFβ/ALK1/Smad1/5 signaling pathway
Figure 1. Coicis semen treatment reduced the infarct volume, improved neurological function and decreased the brain water content in MCAO mice. (A) TTC staining of brain sections from vehicle- or Coicis Semen-treated mice taken at 3 days poststroke. (B, C, D) Effects of Coicis Semen at different concentration on infarct volume, neurological score and brain water content in mice at 3 days poststroke. Mean ± SD. n = 5. aP < 0.05 vs. vehicle; bP < 0.05 vs. Coicis Semen (50 mg/kg). Statistical analyses were performed by one-way ANOVA followed by Tukey’s multiple comparison tests.