Control of lifespan and survival by <i>Drosophila</i> NF-κB signaling through neuroendocrine cells and neuroblasts

Sinan Khor; Dongsheng Cai

doi:doi:10.18632/aging.104196

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Research Paper Volume 12, Issue 24 pp 24604—24622

Control of lifespan and survival by Drosophila NF-κB signaling through neuroendocrine cells and neuroblasts

Figure 3. Lifespan effects of Toll pathway activation in IPCs and neuroblasts are stage-dependent. (A, B) Survival, median lifespan, and 10% max lifespan of elav-Gal4/UAS-CactusRNAi males (blue), tub-Gal80^ts/+;elav-Gal4/UAS-CactusRNAi males (purple), and +/+;UAS-CactusRNAi/+ (black) control males (A). Corresponding lifespan analysis for females (B). (C, D) Survival, median lifespan, and 10% max lifespan of dilp5-Gal4/+;UAS-CactusRNAi/+ males (brown), dilp5-Gal4/+;tub-Gal80^ts/UAS-CactusRNAi males (purple), and +/+;UAS-CactusRNAi/+ (black) control males (C). Corresponding lifespan analysis for females (D). (E, F) Survival, median lifespan, and 10% max lifespan of wor-Gal4/+;UAS-CactusRNAi/+ males (orange), wor-Gal4/+;tub-Gal80^ts/UAS-CactusRNAi males (red), and +/+;UAS-CactusRNAi/+ (black) control males (E). Corresponding lifespan analysis for females (F). Data information: statistics for curve comparisons are shown in the figure. Error bars represent mean ± SEM. **** p<.0001 (log-rank test). n = at least 100 flies for each genotype in lifespan experiments.