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Research Paper Volume 12, Issue 24 pp 25673—25683

Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b+Ly6G- myeloid cells

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Figure 2. Atg7-deletion causes abnormal nucleosome assembly of bone marrow CD11b+Ly6G- myeloid cells. (A) Volcano plot of differentially expressed genes (fold change >2, P-value <0.05) in atg7-deletion compared to wild type CD11b+Ly6G- cells. A total of 237 genes were significantly up-regulated, while 321 genes were down-regulated in atg7-deletion CD11b+Ly6G- cells. non-DE: non-differentially expressed genes. (B) GO enrichment analysis of up-regulated (right) and down-regulated (left) genes. (C) Gene expression heatmap of nucleosome/chromatin assembly-associated genes in atg7-deletion and wild type CD11b+Ly6G- cells. Percentage of nucleosome/chromatin assembly-associated genes out of total number of up-regulated genes. (D) Gene expression heatmap of histone genes in atg7-deletion and wild type CD11b+Ly6G- cells.