Pentoxifylline enhances antioxidative capability and promotes mitochondrial biogenesis for improving age-related behavioral deficits

Yu Wang; Yunxiao Kang; Chunxiao Qi; Tianyun Zhang; Hui Zhao; Xiaoming Ji; Wensheng Yan; Yuanxiang Huang; Rui Cui; Guoliang Zhang; Geming Shi

doi:doi:10.18632/aging.104155

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Research Paper Volume 12, Issue 24 pp 25487—25504

Pentoxifylline enhances antioxidative capability and promotes mitochondrial biogenesis for improving age-related behavioral deficits

Figure 3. Effects of PTX treatment on dopamine and its metabolites in the aged rat brain. (A–C) Effects of PTX treatment on DA, DOPAC, and HVA in the CPu of aged rats. (D–F) Effects of PTX treatment on DA, DOPAC, and HVA in the HIPP of aged rats. Data are expressed as the mean ± S.D. (n=6 rats/group). *P<0.01 versus 6Mon rats, ^#P<0.05 versus 24Mon rats, ^##P<0.01 versus 24Mon rats.