Different doses of ovalbumin exposure on dendritic cells determine their genetic/epigenetic regulation and T cell differentiation

Ying Wang; Zizhong Yu; Yue Zhou; Yun Zhu; Jinhui Wang; Junmei Fu; Yang Yuan; Shan Chen; Yanjun Wang; Wenting Yu; Pei Gao; Wanting Zhu; Qing Cheng; Seong H Cho; Weijia Kong; Jianjun Chen

doi:doi:10.18632/aging.104145

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Research Paper Volume 12, Issue 24 pp 25432—25451

Different doses of ovalbumin exposure on dendritic cells determine their genetic/epigenetic regulation and T cell differentiation

Figure 6. (A) The RPKM value of DC function genes in each dose group in each concentration group. B(1) The RPKM value of the gene induced Th2 cells differentiation in each concentration group. B(2) The RPKM value of the gene induced Th1 cells differentiation in each concentration group. B(3) The RPKM value of the gene induced Treg cells differentiation in each concentration group. C(1) The RPKM value of the gene induced Th2 cells differentiation in 10-0 group. C(2) The RPKM value of the gene induced Th1 cells differentiation in 100-0 group. C(3) The RPKM value of the gene induced Treg cells differentiation in 10000-0 group. DC1/2/3 represents 0ugml DC4/5/6 represents 10ug/ml. DC7/8/9 represents 100ug/ml DC10/11/12 represents 10000ug/ml. Data indicate the mean±SD *p<0.05 represents the differences between the treatment group and the control group. n = 3 independent experiments.