Research Paper Volume 12, Issue 24 pp 25207—25228
Impairment of Pol β-related DNA base-excision repair leads to ovarian aging in mice
Figure 1. Pol β-deficient mouse ovarian function and impaired BER lead to ovarian aging. (D) Pol β+/- mice had lower mean serum AMH concentrations than wt mice (aged 6-8 weeks) (n stands for the number of mice, ***P < 0.001, ANOVA). (E) Reduced primordial follicles per ovary (5-day ovary; n stands for the number of mice, **P < 0.01; Student’s t test); the black arrow indicates oocytes. (F) Reduced primordial follicles per ovary (4-month ovary; n stands for the number of mice, **P < 0.01, Student’s t test); the black arrow indicates oocytes; the blue arrow indicates no oocytes. (G) Reduced ovarian weight in Pol β+/- mice (Mice aged 6-8 weeks; n =8 per group; n stands for the number of ovary, *P < 0.05, Student’s t test).