Deubiquitinase USP7 regulates <i>Drosophila</i> aging through ubiquitination and autophagy

Lang Cui; Wenhao Song; Yao Zeng; Qi Wu; Ziqiang Fan; Tiantian Huang; Bo Zeng; Mingwang Zhang; Qingyong Ni; Yan Li; Tao Wang; Diyan Li; Xueping Mao; Ting Lian; Deying Yang; Mingyao Yang; Xiaolan Fan

doi:doi:10.18632/aging.104067

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Research Paper Volume 12, Issue 22 pp 23082—23095

Deubiquitinase USP7 regulates Drosophila aging through ubiquitination and autophagy

Figure 7. Effect of DMC addition on the senescence traits of dusp7-knockdown Drosophila. (A) Effect of DMC addition on dusp7-knockdown Drosophila (* p<0.05). (B) Effect of DMC addition on heat-stimulation tolerance in dusp7-knockdown Drosophila. (C) Effect of DMC addition on H₂O₂ tolerance in dusp7-knockdown Drosophila (* p<0.05; ** p<0.01; *** p<0.001). (D, E) Effect of DMC addition on paraquat (D) and H₂O₂ (E) tolerance in dusp7-knockdown Drosophila . (>: hybridization).