Research Paper Volume 12, Issue 19 pp 18928—18941
CD8+ T cells are present at low levels in the white matter with physiological and pathological aging
Presence of cytotoxic CD8+ T cells in the white matter of aged individuals. (A) Co-immunofluorescence of CD8 with CD3 marker (n=4). (B) Co-immunofluorescence of CD3 with CD4 marker (n=4). Cell nuclei were counterstained with DAPI. Scale bar: 20 μm. (C, D) Representative images of CD68 and CD163 microglia markers in young and aged individuals (n=3). Images appear to be spliced likely consequence of scanning and were obtained using the 20× objective.