Figure 2 — Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson’s disease patients

Research Paper|Volume 12, Issue 19|pp. 18889–18906

Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson’s disease patients

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Figure 2.Gene expression patterns point to interactions between SNCA overexpression and age-related adaptations in gene activity. (A) Venn diagram comparing DEGs identified in 5- and 12-month-old TG rats. (B) Hierarchically clustered expression changes (relative to WT_5m) for all 934 DEGs identified in 5- and 12-month-old TG rats partitioned into four main perturbance patterns. (C) Gene clusters (see B) summarized as expression medoids (±SD). Cluster cardinalities indicated in brackets.