Research Paper Volume 12, Issue 19 pp 19293—19315
Modification of Mcl-1 alternative splicing induces apoptosis and suppresses tumor proliferation in gastric cancer
Shifted myeloid cell leukemia (Mcl)-1 splicing from Mcl-1L to Mcl-1S suppresses gastric cancer (GC) proliferation in vivo. (A) Change in tumor volume ([end-point volume – initial volume]/initial volume) after treatment with steric-blocking oligonucleotides (SBOs) at indicated dosages is presented. The results of the between-group analyses are shown as the means ± standard deviation. (B) Immunohistochemical staining showing Ki-67 expression levels (red arrows) in tumor sections of the xenograft models, exhibiting changes in tumor viability and proliferation, after treatment with SBOs at indicated dosages is shown.