Figure 5 — Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis

Research Paper|Volume 12, Issue 20|pp. 20163–20183

Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis

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Figure 5.Effects of ciRS-7-related transfections (A) and miR-7-related transfections (B) on protein levels of cartilage-related MMP3, MMP13, and ADAMTS5. Data represent the mean ± SD (n=3), * p < 0.05, ** p < 0.01 and *** p < 0.001 vs. the IL-1β group.