Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis

Xindie Zhou; Jin Li; Yuanshuai Zhou; Zhicheng Yang; Haoyu Yang; Dong Li; Junjie Zhang; Yi Zhang; Nanwei Xu; Yong Huang; Lifeng Jiang

doi:doi:10.18632/aging.103731

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Research Paper Volume 12, Issue 20 pp 20163—20183

Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis

Effects of ciRS-7-related transfections (A) and miR-7-related transfections (B) on mRNA levels of cartilage-related genes MMP3, MMP13, and ADAMTS5; (C) and (D) Zymographic analysis of the effects of ciRs-7 or miR-7 on enzymatic activities of MMP3 and ADAMTS5. Data represent the mean ± SD (n=3), * p < 0.05, ** p < 0.01 and *** p < 0.001 vs. the IL-1β group.