Research Paper
Notch promotes tumor growth and invasion by directly targeting Twist1 in cancer stem cells derived from primary and recurrent glioblastomas
Effect of Notch/Twist1 on orthotopic glioma tumor-bearing mice. (A) Representative bioluminescent images showed tumor growth 8 d after tumor implantation in mice. (B) The survival of mice in different groups. The curve was quantified with a Kaplan-Meier survival curve using Graphpad Prism 8 software. (C) The tumors were collected after mice were sacrificed, and Twist1 mRNA levels in the different groups were measured by RT-qPCR. Data are presented as the mean ± SD. ***: P < 0.001.