Notch promotes tumor growth and invasion by directly targeting Twist1 in cancer stem cells derived from primary and recurrent glioblastomas

Shuwei Wang; Xinru Guo; Wenying Lv; Yanteng Li; Leiming Zhang; Chao Dong; Jianning Zhang; Gang Cheng

doi:doi:10.18632/aging.103728

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Research Paper

Notch promotes tumor growth and invasion by directly targeting Twist1 in cancer stem cells derived from primary and recurrent glioblastomas

Suppression of Twist1 in GSCs inhibited cell proliferation and migration ability in GSCs. (A) The levels of mRNA expression and (B) protein expression in shTwist1 treated-GSCs. (C) NICD and Twist1 mRNA expression, (D) cell proliferation ability, (E) neurosphere formation, and (F) cell migration ability in GSCs after transduction with NICD lentivirus or/and shTwist1. Data are presented as the mean ± SD. *: P < 0.05 and **: P < 0.01. NS represents no significance.