Research Paper
Notch promotes tumor growth and invasion by directly targeting Twist1 in cancer stem cells derived from primary and recurrent glioblastomas
Effect of up- or down-regulation of NICD on cell proliferation and migration ability in GSCs. (A–C) Upregulated NICD promoted cell proliferation, neurosphere formation, and invasion ability of GSCs. The * represents a significant difference from vector-transduced GSCs to NICD-transduced GSCs. (D–F) DAPT suppressed the cell proliferation, neurosphere formation, and invasion ability of GSCs by the transwell assay. Data are presented as the mean ± SD. *: P < 0.05 and **: P < 0.01.