Research Paper
Notch promotes tumor growth and invasion by directly targeting Twist1 in cancer stem cells derived from primary and recurrent glioblastomas
Regulatory relationship of Notch and Twist1 in GSCs. (A, B) Twist1 protein and mRNA levels were significantly increased following NICD lentiviral transduction from day 2-7, while NICD expression level was induced from day 1-7. (C, D) A significant decrease in the levels of NICD and Twist1 protein and mRNA expression in GSCs after treatment with DAPT. Data are presented as the mean ± SD. *: P < 0.05 and **: P < 0.01.