Research Paper
Notch promotes tumor growth and invasion by directly targeting Twist1 in cancer stem cells derived from primary and recurrent glioblastomas
Global gene expression profiles in GSCs from primary and recurrent gliomas. (A) Global gene expression was assayed using the Affymetrix 133 plus 2.0 microarray. The Notch signaling-related and Twist1 genes were notably upregulated. (B–E) Notch signaling-related genes and Twist1 had significant differences in mRNA levels between primary and recurrent GSC lines. Data are presented as the mean ± SD. *: P < 0.05 and **: P < 0.01.