Research Paper Volume 12, Issue 17 pp 17343—17352
High hsa_circ_0020123 expression indicates poor progression to non-small cell lung cancer by regulating the miR-495/HOXC9 axis
Figure 5. Interactions among hsa_circ_0020123, miR-495 and HOXC9. (A) Prediction of binding sites of miR-495 in hsa_circ_0020123. The mutant (MUT) version of hsa_circ_0020123 is presented. (B) Relative luciferase activity determined 48 h after transfection of HEK293T cells with miR-495 mimic/NC or hsa_circ_0020123 wild-type (WT)/Mut. Data are presented as means ± SD. ***P < 0.001. (C) Prediction of binding sites of miR-495 within the 3'UTR of HOXC9. The MUT version of 3'-UTR-HOXC9 is shown. (D) Relative luciferase activity determined 48 h after transfection of HEK293T cells with miR-495 mimic/NC or 3'UTR-HOXC9 WT/Mut. Data are presented as means ± SD. ***P < 0.001.