Research Paper Volume 12, Issue 18 pp 18322—18342

Figure 4. Screening of the two-gene-based signatures in PC patients. (A) After 3000 analyses, ANLN and HIST1H1C appeared more than 2500 times as the independent prognostic genes among 35 survival related genes. (B–D) The boxplot shows that ANLN were constantly high-expressed in GSE28735, GSE62452 and TCGA. (E–G) The boxplot shows that HIST1H1C were constantly high-expressed in GSE28735, GSE62452 and TCGA. (H) The heatmap of ANLN and HIST1H1C mRNA expression in PC cells from Cancer Cell Line Encyclopedia. (I) the Human Protein Atlas project shows representative immunohistochemical images of ANLN and HIST1H1C in PC tissues compared with surrounding normal tissues.