Research Paper Volume 12, Issue 18 pp 18238—18250
The mitochondrial-targeted peptide SBT-20 ameliorates inflammation and oxidative stress in chronic renal failure
Figure 6. SBT-20 decreases oxidation in CRF mice. (A) TUNEL assay was performed in mice. (B) RT-PCR was performed to detect oxidative stress-relative markers, HIF-1α, HO-1, SOD1 and SOD2. n=5. (C) Cleaved-caspase3 expression intensity was evaluated by IHC assay. (D) Western blot was performed to measure the expression of cleaved-caspase3 in renal tissues. n=5. (*P<0.05 vs. sham group, #P<0.05 vs. CRF group).