Review Volume 12, Issue 21 pp 22313—22334

Figure 2. Schematic of the physiological role of α-Syn in synaptic transmission. The figure shows that α-Syn (monomeric and tetrameric forms) is involved in neurovesicle transport during the intricate transmission of neurotransmitters in synapses, dendrites and axons; this transport includes neurotransmitter vesicle storage, aggregation, assembly and release, as well as recovery and inhibition of neurotransmitters and other circulatory processes. α-Syn is also involved in the maintenance of cell membrane homeostasis and the normal functioning of mitochondria and lysosomes.