Research Paper Volume 12, Issue 19 pp 19022—19044
Target RNA modification for epigenetic drug repositioning in neuroblastoma: computational omics proximity between repurposing drug and disease
Detailed chart for therapeutic targets discovery (A) and drug discovery (B). (A) The prognostic potential of differentially expressed genes (DEGs) and RNA modification regulators (RNA-MRs) in cluster1 (severe NBL) were analyzed. Genes correlated to survival formed prognostic DEGs set and prognostic RNA-MRs set, respectively. Then function-related prognostic DEGs were identified from prognostic DEGs as genes positively related to prognostic RNA-MRs. The function-related prognostic DEGs and prognostic RNA-MRs together formed core prognostic gene set. (B) The reversed similarities of gene expression pattern in DEGs and core prognostic gene set were calculated in L1000FWD respectively. The same records in two searches were integrated according to target type. The reversed similarities of core prognostic gene set only was calculated in CMap. Then inhibitors from L1000FWD and CMap were summarized according to target type. PR: progesterone receptor; SFU: sodium fluorescein uptake; MR: Mineralocorticoid receptor; MOP: Mitochondrial oxidative phosphorylation; RNAP: RNA polymerase.