Research Paper Volume 12, Issue 18 pp 18127—18136

GHR knockdown enhances the sensitivity of HCC cells to sorafenib

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Figure 5. GHR knockdown enhanced sorafenib inhibiting of cell migration. (A) Wound healing assay measured cell migration of HCC cells siGHR or/and sorafenib; (B) the width ratio was calculated by the wound width/the distance measured at 0 h. All data shown represented the mean ± SEM. ***p<0.001; (C) The results of western blotting assay showed that GHR knockdown and sorafenib combination suppressed the protein levels of MMP2 and MMP9 and promoted the expression of E-cadherin in HepG2 and Huh7 cells.