Research Paper Volume 12, Issue 18 pp 18127—18136
GHR knockdown enhances the sensitivity of HCC cells to sorafenib
Figure 3. GHR knockdown enhanced sorafenib suppressing of the activation of PI3K/AKT/ERK1/2 signaling pathways. The results of western blotting assay revealed that the protein levels of ERK1/2, p-ERK1/2, PI3K, p-PI3K, AKT and p-AKT were significantly inhibited in HepG2 (A) and Huh7 cells (B) with siGHR and sorafenib combination compared with cells with sorafenib single.