Research Paper Volume 12, Issue 18 pp 18052—18072

Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles

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Figure 3. MVs derived from cell culture media. (A) Transmission electron microscopy (TEM) micrograph of EVs isolated from cell culture media. (B) Microscopy image showed the internalization of fluorescently labeled EVs into recipient HPTCs with Dil-C18 (red).