Research Paper Volume 12, Issue 16 pp 16099—16110

IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease

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Figure 3. MiR-423-5p could bind with the 3'UTR of claudin-5. (A) Binding sequences between miR-423-5p and claudin-5 (CLDN5) (http://www.targetscan.org/cgi-bin/targetscan/vert_72/view_gene.cgi?rs=ENST00000406028.1&taxid=9606&members=miR-423-5p&showcnc=1&shownc=1&shownc_nc=1&showncf1=&showncf2=&subset=1). The luciferase assay report. n=3. (B, C) The expression of claudin-5 in colorectal epithelial cell lines. n=4. (D) The level of miR-423-5p in colonic mucosa from UC patients and healthy volunteers. n=15. (E) Representative images of immunofluorescence staining with claudin-5. *P < 0.05, **P < 0.01