Research Paper Volume 12, Issue 14 pp 15021—15036

Figure 3. NVD-BM inhibits melanoma proliferation in xenograft mice. (A) Subcutaneous tumors generated in BALB/c-nu/nu mice, with NVD-BM transduced A375 cells. A375 cells transduced with blank lentiviral vector, and vectors expressing pCDH and NVD-BM were collected and subcutaneously injected into BALB/c-nu/nu mice, at a cell density of 1×10⁷ to elicit tumorigenicity. Tumors were removed and diameters measured (n = 4/group) ± standard deviation (SD). (B) Hematoxylin eosin (HE) tumor staining in transduced A375 cells. Nuclei are blue. Cytoplasm is red. Magnification × 200.