Figure 6.DMC-BH reduces GSCs intracranial orthotopic growth. (A) GSCs intracranial orthotopic growth after DMC-BH treatment measured by Bioluminescent Imaging (BLI). (B) The average tumor volume in intracranial analyzed by ROI recording. (C) Proliferation of intracranial tumor analyzed using the Ki67 biomarker.
(D) Apoptosis of intracranial tumor analyzed by TUNEL assay. (E) Western analysis of c-caspase-3, LC3-II, p-ERK and p-JNK levels in intracranial tumors. (F) Body weight loss in DMC-BH-treated and control mice; n =10.
