Melatonin protects against apoptosis of megakaryocytic cells via its receptors and the AKT/mitochondrial/caspase pathway

Mo Yang; Liang Li; Shichao Chen; Suyi Li; Bo Wang; Changhua Zhang; Youpeng Chen; Liuming Yang; Hongwu Xin; Chun Chen; Xiaojun Xu; Qing Zhang; Yulong He; Jieyu Ye

doi:doi:10.18632/aging.103483

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Research Paper Volume 12, Issue 13 pp 13633—13646

Melatonin protects against apoptosis of megakaryocytic cells via its receptors and the AKT/mitochondrial/caspase pathway

Figure 7. Melatonin promotes the formation of CFU. The number of CFUs was scored after melatonin (100 nM) or TPO (positive control, 50 ng/mL) treatments for seven days (n=6). (A) Bone marrow histology of Giemsa staining. (B) Statistic analysis of CFUs. Two-way ANOVA (with a Tukey multiple comparison test) was employed to test for significance (n=6). ** p< 0.01. CFU-MK, colony- forming unit-megakaryocyte; CFU-GM, colony-forming unit-granulocyte macrophage; BFU/CFU-E, burst-forming unit/colony-forming unit-erythroid; CFU-GEMM, colony-forming unit-mixed.