Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome

Raneem Habib; Ryong Kim; Heidemarie Neitzel; Ilja Demuth; Krystyna Chrzanowska; Eva Seemanova; Renaldo Faber; Martin Digweed; Reinhard Voss; Kathrin Jäger; Karl Sperling; Michael Walter

doi:doi:10.18632/aging.103453

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Research Paper Volume 12, Issue 12 pp 12342—12375

Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome

Figure 4. (A) Relative telomere length (TL) of three tissues of humanized Nbs mice as estimated by qPCR. Relative TL (T/S ratio) in brain, heart, and liver tissues of humanized Nbs mice (Nbn^-/-NBN^del, in the figure labelled Nbn^-) 87, 68 and 92 (age: 32, 41, and 39 days) and humanized wild-type mice (Nbn^-/-NBN⁺, in the figure labelled Nbn⁺): 95 and 98 (age: 32 days) estimated by qPCR. (B) Relative TL of an NBS fetus. Relative TL ±SD (T/S ratio) in 14 different tissues of a 32 week old NBS-fetus estimated by qPCR. Original from [28].