Research Paper Volume 12, Issue 15 pp 15290—15301

Figure 6. In vivo evaluation of targeting tumor-infiltrating neutrophils (TINs) and PD-L1 to treat glioblastomas (GBMs) in mice. The study flow of animal experiments (A). The representative image of tumor changes before and after antibody treatments (B). The tumor sizes significantly decreased with the dual therapy comprising anti- PD-1 and depletion of neutrophils compared to those in the control groups (C). Survival analysis showed that the mice receiving dual therapy had the longest survival times (D).