Figure 1. Apigenin ameliorates renal fibrosis and inflammatory gene expression in diabetic rats. (A) Representative photographs of MT staining (scale bar: 100 μm) and IHC of Kim-1 in the tubulointerstitial area (scale bar: 100 μm) and the mitochondrial morphology observed under transmission electron microscopy (TM) scale bar: 500 nm). (B–E) Quantitative RT-PCR of collagen III (B), Kim-1 (C), TNF-α (D), and IL-6 (E) mRNA normalized to expression of 18S, in the renal cortex (n=6). All data represent the mean ± standard deviation (SD). *p<0.01 vs. other groups. ZLRs; Zucker lean rats, ZDFRs; Zucker diabetic fatty rats.