Research Paper Volume 12, Issue 13 pp 13172—13186
An individualized transcriptional signature to predict the epithelial-mesenchymal transition based on relative expression ordering
Figure 1. Workflow of our study. (A) Schematic diagram of the EMT. (B) Identification of the EMT signature (16-GPS). (C) Validation of the 16-GPS. In the independent validation cohorts, patient samples were classified as epithelial-like (E-like) or mesenchymal-like (M-like). The utility of 16-GPS was then validated by evaluating classification accuracy with ROC curves and associations with prognosis, immunology, and metastases.