Identification of immunological subtypes of hepatocellular carcinoma with expression profiling of immune-modulating genes

Di Cao; Meng-Ke Chen; Qing-Feng Zhang; Yu-Feng Zhou; Mei-Yin Zhang; Shi-Juan Mai; Yao-Jun Zhang; Min-Shan Chen; Xiao-Xing Li; Hui-Yun Wang

doi:doi:10.18632/aging.103395

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Research Paper Volume 12, Issue 12 pp 12187—12205

Identification of immunological subtypes of hepatocellular carcinoma with expression profiling of immune-modulating genes

Figure 5. Survival curves of HCC patients stratified by combined CD8 expression and B7-H3 or CD47 expression in TCGA-LIHC cohort. (A) Overall survival curves of HCC patients stratified by the combined expressions of B7-H3 (CD276) and CD8: the survival of patients with B7-H3^low/CD8^high is significantly better than that of those with B7-H3^high/CD8^high (P = 0.004), B7-H3^high/CD8^low (P = 0.001) or B7-H3^low/CD8^low (P = 0.012) and no significance between other groups. (B) Survival curves of HCC patients stratified by the combined expressions of CD47 and CD8: the survival of patients with CD47^high/CD8^low is significantly worse than that of those with CD47^low/CD8^high (P = 0.008) or CD47^low/CD8^low (P = 0.045), and no significance between other groups (log rank test). H represents high and L represents low respectively.