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Research Paper Volume 12, Issue 20 pp 20069—20084
LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2
Low miR-129-5p expression correlates with advanced tumor stage and poor survival of glioma patients. (A) Pearson correlation analysis shows the relationship between FAM181A-AS1 and miR-129-5p expression in glioma patients from the CGGA database. (B) QRT-PCR analysis shows miR-129-5p expression in the four glioma cell lines and the control NHA cell line. (C) QRT-PCR analysis shows miR-129-5p expression in patients with WHO stage II/III or WHO stage IV glioma from the CGGA database. (D) ROC curve analysis shows the sensitivity and specificity and AUC value of miR-129-5p expression in glioma samples. (E) Kaplan-Meier survival curve analysis shows the overall survival of glioma patients with high or low miR-129-5p expression. Note: **P<0.01, ***P<0.001; data are represented as means ± SD.