Research Paper Volume 12, Issue 12 pp 11942—11966

Figure 2. Associations between Seven BoAs and lung function for 696 men (1,070 visits), the NAS, 1999-2013. For GrimAgeAccel, PhenoAgeAccel, TL, and mtDNA-CN, we adjusted for chronological age, BMI, height, smoking status, cigarette pack-years, years of education, corticosteroid use, estimated cell types, and batch effects. For EEAA and IEAA, we adjusted for chronological age, BMI, height, smoking status, cigarette pack-years, years of education, corticosteroid use, and batch effects. For Zhang’s DNAmRiskScore, we adjusted for chronological age, BMI, height, smoking status, cigarette pack-years, years of education, corticosteroid use, estimated cell types, batch effects, and technical covariates: Non polymorphic Red, Specificity I Red, Bisulfite Conversion I Red, Bisulfite Conversion II, Extension Red. Abbreviations: IEAA = intrinsic epigenetic age acceleration; EEAA = extrinsic epigenetic age acceleration; TL = Telomere length; mtDNA-CN = mitochondrial DNA copy number; BoA = biomarkers of aging; BMI = body mass index; FDR_B-H = Benjamin-Hochberg false discovery rate.