PLK1 Inhibition alleviates transplant-associated obliterative bronchiolitis by suppressing myofibroblast differentiation

Jizhang Yu; Heng Xu; Jikai Cui; Shanshan Chen; Hao Zhang; Yanqiang Zou; Jing Zhao; Sheng Le; Lang Jiang; Zhang Chen; Hao Liu; Dan Zhang; Jiahong Xia; Jie Wu

doi:doi:10.18632/aging.103330

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Research Paper Volume 12, Issue 12 pp 11636—11652

PLK1 Inhibition alleviates transplant-associated obliterative bronchiolitis by suppressing myofibroblast differentiation

Figure 8. PLK1 knockdown inhibits TGFβ-mediated differentiation of human myofibroblasts. (A) Schematic depicting establishment of the recombinant plasmid RSV-PLK1-shRNA. (B) A representative image of infected human primary myofibroblast cells. (C–F) The expression of [50] α-SMA was analyzed by WB (C, D), qRT-PCR (E, F), and IF (G). (H) Migration ability of myofibroblasts in the control and PLK1-shRNA-treated groups.