Expression of Concern
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This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
Research Paper Volume 12, Issue 12 pp 11568—11578
Integrative analysis of miRNAs-mRNAs reveals that miR-182 up-regulation contributes to proliferation and invasion of nasopharyngeal carcinoma by targeting PTEN
Figure 4. MiR-182 promoted proliferation and invasion of NPC cells via targeting PTEN. (A) The complementary binding sites of miR-182 and 3′UTR of PTEN. (B) The dual-luciferase reporter assays were performed to verify the target prediction. (C) MiR-182 mimics/inhibitors significantly reduced/increased PTEN expression. (D) PTEN expression was significantly increased after transfection. (E) Overexpression of PTEN abrogates the promotion effect of miR-182 mimics on NPC invasion. P < 0.05.