SPTBN1 suppresses the progression of epithelial ovarian cancer via SOCS3-mediated blockade of the JAK/STAT3 signaling pathway

Mo Chen; Jia Zeng; Shuyi Chen; Jiajia Li; Huijie Wu; Xuhui Dong; Yuan Lei; Xiuling Zhi; Liangqing Yao

doi:doi:10.18632/aging.103303

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Research Paper Volume 12, Issue 11 pp 10896—10911

SPTBN1 suppresses the progression of epithelial ovarian cancer via SOCS3-mediated blockade of the JAK/STAT3 signaling pathway

Figure 3. SPTBN1 inhibits the migration and EMT of epithelial ovarian cancer cells. (A, B) Assessments of cell migration. Overexpression of SPTBN1 inhibits the migration of HO8910 cells (A), while downregulation of SPTBN1 promotes the migration of A2780 cells (B). (C, D) Comparison of EMT-related markers at the protein level (C) and mRNA level (D). * P < 0.05, **P < 0.01 vs Con-sh, n=3.