miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of <i>Src</i>-mediated MAPK signaling pathway in ischemic stroke

Runhui Tian; Bo Wu; Cong Fu; Kaimin Guo

doi:doi:10.18632/aging.103301

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Research Paper Volume 12, Issue 11 pp 10873—10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

Figure 9. Downregulated miR-137 accelerates cerebral infarction and impairs neuronal functions and learning and memory abilities in MCAO mice. (A) neurological function scores in miR-137^-/- mice; (B) rate of left limb fault step of miR-137^-/- mice by foot-fault test; (C) latency period and number of errors of miR-137^-/- mice in the step-down test; (D) changes in volume of infarct of miR-137^-/- mice using TTC staining; (E) changes in number of neurons in miR-137^-/- mice using Nissl staining (× 400). Measurement data are expressed as mean ± standard deviation and compared using one-way ANOVA, followed by Tukey's post hoc test. * p < 0.05 vs. control group (sham-operated wild-type mice); # p < 0.05 vs. MCAO group (wild-type mouse models of MCAO). N = 15.