Figure 6 — miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

Research Paper|Volume 12, Issue 11|pp. 10873–10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

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Figure 6.Knockout of Src gene restricts oxidative stress and the expression of inflammatory markers in the brains of MCAO mice. (A) ROS content in the brain tissues of Src^-/- mice was measured using a DCFH-DA fluorescent probe; (B) TNF-α, IL-1, IL-6, IL-17 and IL-10 expression in the brain tissues of Src^-/- mice using ELISA. Measurement data are expressed as mean ± standard deviation and compared by one-way ANOVA, followed by Tukey's post hoc test. * p < 0.05 vs. control group (sham-operated wild-type mice); # p < 0.05 vs. MCAO group (wild-type mouse models of MCAO); N = 15.