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Research Paper Volume 12, Issue 11 pp 10873—10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

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Figure 2. Inhibition of p38 or Erk2 ameliorates cerebral infarction and improves neuronal function, learning, and memory abilities in MCAO mice. (A) neurological function scores in mice in each group; (B) rate of left limb fault step of mice after treatment with si-p38, si-Erk2 or in combination; (C) latency period and number of errors of mice treated with si-p38, si-Erk2 or in combination; (D) changes in the volume of infarct in mice treated with si-p38, si-Erk2 or in combination using TTC staining; (E) changes in the number of neurons from mice treated with si-p38, si-Erk2 or in combination using Nissl staining (× 400). Measurement data are expressed as mean ± standard deviation and compared by one-way ANOVA, followed by Tukey's post hoc test; * p < 0.05 vs. control group (sham-operated wild-type mice); # p < 0.05 vs. MCAO group (wild-type mouse models of MCAO). N = 15.